Adenylic Acid and Adenosine Deaminase Activities in Rat Livers During Azo-Dye Carcinogenesis.

Abstract

Adenosine and adenylic acid deaminase activities were determined in precancerous livers and in primary hepatomas induced by feeding 3′-methyl-4-dimethylamino-azobenzene. The deaminase activities in precancerous livers were increased about 100% after 30 days of dye feeding compared with control livers. Activities in primary hepatomas and in the liver adjacent to primary hepatomas were essentially the same as that of precancerous livers, indicating that no additional changes occurred upon formation of neoplastic tissues.