Classification of ? 1-antitrypsin (Pi) phenotypes by isoelectrofocusing

Abstract

Pi phenotypes have been determined by isoelectrofocusing in a sample of 538 healthy individuals from Southern Germany. Further subdivision of the common PiM phenotype is described. A procedure for the delineation of six common subtypes is presented. It is assumed that the six subtypes are determined by three alleles which are provisionally called Pi^Ma, Pi^Mb, and Pi^Mc. Their frequencies in this sample were 0.75, 0.06, and 0.15, respectively.