Correction of Hypertriglyceridemia and Impaired Fat Tolerance in Lipoprotein Lipase–Deficient Mice by Adenovirus-Mediated Expression of Human Lipoprotein Lipase
- 1 November 1997
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 17 (11), 2532-2539
- https://doi.org/10.1161/01.atv.17.11.2532
Abstract
Humans homozygous or heterozygous for mutations in the lipoprotein lipase (LPL) gene demonstrate significant disturbances in plasma lipoproteins, including raised triglyceride (TG) and red...Keywords
This publication has 30 references indexed in Scilit:
- Efficient Adenovirus-Mediated Ectopic Gene Expression of Human Lipoprotein Lipase in Human Hepatic (HepG2) CellsHuman Gene Therapy, 1997
- Premature Atherosclerosis in Patients with Familial Chylomicronemia Caused by Mutations in the Lipoprotein Lipase GeneNew England Journal of Medicine, 1996
- Oxidation of Low Density Lipoproteins Greatly Enhances Their Association with Lipoprotein Lipase Anchored to Endothelial Cell MatrixPublished by Elsevier ,1996
- Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.JCI Insight, 1995
- Expression of lipoprotein lipase mRNA and secretion in macrophages isolated from human atherosclerotic aorta.JCI Insight, 1993
- Assessment of Recombinant Adenoviral Vectors for Hepatic Gene TherapyHuman Gene Therapy, 1993
- Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.JCI Insight, 1993
- Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities.JCI Insight, 1993
- Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques.JCI Insight, 1992
- Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.JCI Insight, 1991