Preweanling Rats: Recovery from Lateral Hypothalamic Damage.
- 1 January 1976
- journal article
- research article
- Published by American Psychological Association (APA) in Journal of Comparative and Physiological Psychology
- Vol. 90 (11), 1063-1074
- https://doi.org/10.1037/h0078661
Abstract
Preweanling male and female albino rats sustained lateral hypothalamic area (LHA) destruction at 10 days of age. Pups with bilateral LHA destruction (Bi-LHA) displayed the lateral hypothalamic recovery syndrome (LHRS) and recovered voluntary feeding and drinking between 44-75 days of age. The Bi-LHA rats of both sexes showed permanent deficits (through 200-275 days of age) in responding to hydrational challenges and did not feed in response to 2-deoxy-D-glucose treatment. Male Bi-LHA rats'' body weights were permanently depressed by 20%-25%, whereas female body weight, depression was only temporary. Rats sustaining LHA destruction on 1 side of the brain (Uni-LHA) displayed an abbreviated LHRS, recovering voluntary feeding and drinking by 25-32 days of age. The Uni-LHA rats showed some permanent deficits in responding to hydrational challenges, yet they displayed the same sex differential for body weight regulation as the Bi-LHA rats. The results of this investigation demonstrate nearly identical effects of LHA destruction whether sustained during preweaning, postweaning or adulthood.This publication has 2 references indexed in Scilit:
- Aphagia and adipsia following unilateral and bilaterally asymmetrical lesions in ratsPhysiology & Behavior, 1967
- The Effect of Hypovolemia on Drinking in Rats With Lateral Hypothalamic Damage.Experimental Biology and Medicine, 1967