Tumor Reoxygenation and Postirradiation Vascular Changes

Abstract

Postirradiation reoxygenation kinetics of the Walker 256 rat carcinoma were examined and related to radiation-induced changes in tumor vascular functions. Changes in the hypoxic cell component of irradiated Walker tumors may occur by 2 mechanisms. Reoxygenation of previously hypoxic cells may be due to an increased rate of blood flow in some parts of the tumor. Hypoxic tumor cells may also be eliminated by cell death due to prolonged or severe hypoxia in other parts of the tumor as a result of substantial damage to the tumor vasculature as seen in radiation-induced changes in vascular volume and blood vessel permeability. Reoxygenation of experimental tumors following single, massive doses of radiation may be different from that occurring in human tumors during the course of multifraction radiotherapy.