Immunological evaluation of novelMycobacterium tuberculosisculture filtrate proteins
- 1 February 1999
- journal article
- Published by Oxford University Press (OUP) in FEMS Immunology & Medical Microbiology
- Vol. 23 (2), 159-164
- https://doi.org/10.1111/j.1574-695x.1999.tb01235.x
Abstract
Culture filtrate from Mycobacterium tuberculosis contains molecules which can promote protective immunity to tuberculosis in animal models. Six novel proteins in the region of 17-29 kDa were purified and investigated for their immunological relevance in M. tuberculosis-infected mice, guinea pigs and tuberculosis patients. The proteins CFP17, CFP21, CFP25 and CFP29 were all identified as strong interferon-gamma inducers in M. tuberculosis-infected mice and in tuberculosis patients. The CFP21 protein is encoded in the genomic region RD-2 which is deleted from a number of BCG strains and the diagnostic potential of this antigen was evaluated.Keywords
This publication has 27 references indexed in Scilit:
- Immunological requirements for a subunit vaccine against tuberculosisImmunology & Cell Biology, 1997
- Immunogenicity and protective efficacy of a tuberculosis DNA vaccineNature Medicine, 1996
- Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovisJournal of Bacteriology, 1996
- Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences, 1995
- T Cell Response to Mycobacterium tuberculosisThe Journal of Infectious Diseases, 1993
- Simultaneous electroelution of whole SDS-polyacrylamide gels for the direct cellular analysis of complex protein mixturesJournal of Immunological Methods, 1993
- The BCG Story: Lessons from the Past and Implications for the FutureClinical Infectious Diseases, 1989
- Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccinesInfection and Immunity, 1988
- Cross‐reactions between MycobacteriaScandinavian Journal of Immunology, 1979
- THE RELATIONSHIP OF DELAYED HYPERSENSITIVITY TO ACQUIRED CELLULAR RESISTANCEBritish Medical Bulletin, 1967