Platelet monoamine oxidase activity and genetic vulnerability to schizophrenia
- 1 July 1984
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 141 (7), 836-842
- https://doi.org/10.1176/ajp.141.7.836
Abstract
Platelet monoamine oxidase (MAO) activity determined in 102 patients with chronic schizophrenia, 223 1st-degree relatives and 88 normal control subjects was shown to be a heritable and stable trait and was significantly lower in patients than in normal control subjects. Within families, MAO activity distinguished ill from well relatives. The considerable overlap in enzyme activity between affected and unaffected individuals limits the usefulness of low MAO activity as a major risk factor in schizophrenia.This publication has 32 references indexed in Scilit:
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