Stero-bile Acids and Bile Alcohols* LXXXVIII. Formation of Bile Acids and Alcohols from Cholestanol and 7α-Hydroxycholesterol in the Carp

Abstract

The in vivo conversion of cholestanol and 7α-hydroxycholesterol to bile salts was studied in the carp. 1. When cholestanol-5, 6-³H was injected intraperitoneally into carp, radioactive 5α-cyprinol, 27-deoxy-5α-cyprinol and allocholic acid were isolated from the gall-bladder bile. 2. After intraperitoneal injection of 7α-hydroxycholesterol-7β-³H into carp, the metabolites excreted in the bile were shown to be 5α-cyprinol, 27-deoxy-5α-cyprinol, allocholic acid and cholic acid.