Targeting of cytotoxic agents by polyamines: synthesis of a chlorambucil–spermidine conjugate
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 298-300
- https://doi.org/10.1039/c39920000298
Abstract
An efficient synthesis of the chlorambucil–spermidine conjugate 4 has been achieved via N1,N8-bis-Boc-spermidine and 4 has been shown to crosslink DNA 104 times more efficiently than chlorambucil itself.Keywords
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