Localization of specialized noradrenaline receptors at neuromuscular junctions on arterioles of the guinea‐pig.

Abstract

Noradrenaline [norepinephrine, NA] was applied by ionophoresis to various positions on the surface of an arteriole, and any changes in membrane potential of the arteriolar smooth muscle were recorded. At a proportion of positions NA produced membrane depolarization. The positions where NA produced these membrane potential changes were restricted to regions close to the sympathetic nerves which innervated the arterioles.