Identification of Inhibitors for UDP-Galactopyranose Mutase
- 5 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (34), 10532-10533
- https://doi.org/10.1021/ja048017v
Abstract
The flavoenzyme uridine 5'-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16 000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified.This publication has 11 references indexed in Scilit:
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