α-Melanocyte-Stimulating Hormone: Reduction in Adult Rat Brain After Monosodium Glutamate Treatment of Neonates
- 24 August 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4408), 827-829
- https://doi.org/10.1126/science.462194
Abstract
Intraperitoneal injection of monosodium glutamate in neonatal rates resulted in a 90 percent loss of alpha-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of alpha-melanocyte-stimulating hormone in the brain suggests that is primary source there is the neuronal perikarya of the arcuate nucleus.Keywords
This publication has 54 references indexed in Scilit:
- Opioid peptides and their relativesNature, 1979
- Axon-Sparing Brain Lesioning TechniqueScience, 1978
- Electron microscopic immunohistochemical localization of α‐MSH in the rat brainJournal of Anatomy, 1977
- Growth, endocrinological and behavioral deficits after monosodium l-glutamate in the neonatal rat: possible involvement of arcuate dopamine neuron damagePsychoneuroendocrinology, 1977
- Synthesis of luteinising hormone releasing factor and thyrotropin-releasing factor in glutamate-lesioned miceNature, 1976
- Monosodium glutamate induced lesions of the arcuate nucleus. I. Endocrine deficiency and ultrastructure of the median eminenceThe Anatomical Record, 1976
- The Effects of Neonatally-Administered Monosodium Glutamate on the Reproductive System of Adult Hamsters1Biology of Reproduction, 1976
- ACCUMULATION OF GLUTAMIC ACID IN THE ARCUATE NUCLEUS OF THE HYPOTHALAMUS OF THE INFANT MOUSE FOLLOWING SUBCUTANEOUS ADMINISTRATION OF MONOSODIUM GLUTAMATE1Journal of Neurochemistry, 1972
- Effect of Monosodium Glutamate on Some Endocrine FunctionsNeuroendocrinology, 1971
- Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium GlutamateScience, 1969