Suppressor of Hairless, the Drosophila homologue of RBP-J.KAPPA., transactivates the neurogenic gene E(spl)m8.
- 1 January 1995
- journal article
- Published by Genetics Society of Japan in The Japanese Journal of Genetics
- Vol. 70 (4), 505-524
- https://doi.org/10.1266/jjg.70.505
Abstract
Suppressor of Hairless [Su(H)], the Drosophila homologue of RBP-Jκ is a novel type of sequence-specific DNA binding protein without known motifs, and highly conserved in various organisms. Su(H) regulates peripheral nervous system (PNS) development. Recently Su(H) was suggested to participate in the Notch-mediated signal transduction pathway. We show here that the Su(H) protein binds to TGTGGGAA sequence located 616 base-pairs upstream of the transcription initiation site of the Enhancer of split [E(spl)]m8 gene which is mapped to the terminus of the genetic cascade of the neurogenic genes. Su(H) transactivates the E(spl)m8 promoter not only in cultured Drosophila cells but also in vivo. The present study bridges the biochemical gap between Notch and E(spl) in the neurogenic gene cascade including Delta, Notch, deltex, Su(H), Hairless and E(spl).Keywords
This publication has 59 references indexed in Scilit:
- The suppressor of hairless protein participates in notch receptor signalingCell, 1994
- Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J κScience, 1994
- Genetic characterization of Drosophila RBP-J.KAPPA. (Suppressor of Hairless) as a neurogenic gene in adult PNS development.The Japanese Journal of Genetics, 1994
- Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fatesCell, 1992
- The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system developmentCell, 1992
- A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinaseCell, 1992
- TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsCell, 1991
- A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motifNature, 1989
- Vectors for Drosophila P-element-mediated transformation and tissue culture transfectionGene, 1988
- Genetic Transformation of Drosophila with Transposable Element VectorsScience, 1982