Chromatin-level regulation of biosynthetic gene clusters
Top Cited Papers
- 17 May 2009
- journal article
- research article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 5 (7), 462-464
- https://doi.org/10.1038/nchembio.177
Abstract
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.Keywords
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