It is my intention to summarize the investigations in childhood schizophrenia carried on over the past ten years at the Ittleson Center for Child Research. These investigations have not constituted a very rigidly organized and totally preplanned program of research. However, primary research objectives were carefully enunciated and each of the studies did emerge naturally out of previous ones. In this sense, they did add up to an interrelated chain of explorations. The investigations were ordered by an evolving set of concepts and derivative hypothetical propositions. Ordinarily, when in the midst of an investigative task, the investigator is likely to dissociate the scientific undertaking from its philosophical implications. I particularly welcome the opportunity to describe the major findings of the Ittleson studies, therefore, since a distillation of the data and trends as they emerged sequentially might illuminate the scientific logic and