Circulatory reflexes from carotid and extracarotid baroreceptor areas in man.
- 1 September 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 41 (3), 309-315
- https://doi.org/10.1161/01.res.41.3.309
Abstract
The carotid sinus baroreceptor reflex was studied in 11 normotensive subjects, using a variable pressure neck chamber and correcting for imperfect pressure transmission to the carotid sinus. Decreased carotid baroreceptor stimulation caused a sustaineded rise in arterial pressure, and increased carotid baroreceptor stimulation caused a sustain fall. The responses were in linear relation to the stimulus, and, after reaching the steady state, greater for the reduced than for the increased baroreceptor stimulation. Thus the carotid sinus baroreceptor reflex of the normotensive man is an effective antihypotensive and antihypertensive feedback system, though the former function may have more sensitivity. The increased and decreased baroreceptor stimulation by the neck chamber also caused bradycardia and tachycardia which were modest in magnitude and often transient. In eight subjects the reflex changes in heart rate induced by the neck chamber were compared with those induced by altering transmural pressure not merely at the carotid sinus but throughout the arterial tree (injection of phenylephrine and trinitroglycerin). The slopes of these relations were 3 times as great in the latter circumstance. Thus the carotid baroreceptors play a lesser role in heart rate control than do extracarotid baroreceptors.This publication has 16 references indexed in Scilit:
- Cardiovascular Responses to Changes in Carotid Sinus Transmural Pressure in ManActa Physiologica Scandinavica, 1975
- 'Steady-state' properties of the baroreceptor-heart rate reflex in essential hypertension in manClinical and Experimental Pharmacology and Physiology, 1974
- Reflex Diuresis during Tachycardia in the DogCirculation Research, 1973
- Comparison of aortic and carotid baroreflexes in the dogThe Journal of Physiology, 1971
- The effects of changes of extramural, ‘intrathoracic’, pressure on aortic arch baroreceptorsThe Journal of Physiology, 1971
- Reflex heart rate control in manAmerican Heart Journal, 1970
- The role of skin and muscle resistance vessels in reflexes mediated by the baroreceptor systemJournal of Clinical Investigation, 1970
- Quantitative Untersuchungen ber die Bedeutung der Gef dehnungsreceptoren im Rahmen der Kreislaufhomoiostase beim wachen MenschenPflügers Archiv - European Journal of Physiology, 1967
- Circulatory effects of stimulating the carotid arterial stretch receptors in man at rest and during exercise.Journal of Clinical Investigation, 1966