Evolution and resolution of oedema following severe temporary cerebral ischaemia in the gerbil.
Open Access
- 1 June 1984
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 47 (6), 604-610
- https://doi.org/10.1136/jnnp.47.6.604
Abstract
Regional cerebral blood flow (rCBF) and oedema following profound temporary ischaemia were studied in the gerbil. Ninety-four per cent of animals died within 24 hours of reperfusion; 50% by 4 hours. Regional differences in oedema (specific gravity method), Evans blue (EB) staining and rCBF (hydrogen clearance technique) occurred. Oedema developed during arterial occlusion, being inversely proportional to residual flow and was markedly exacerbated during reperfusion. Reperfusion hyperaemia was maximal in the parietal and hippocampal regions (ischaemic rCBF 4 ml 100 g-1 min-1). Oedema was disappearing in all areas by 3 hours of reperfusion and autoregulation returned in the occipital region (mean ischaemia rCBF 8 ml 100 g-1 min-1). EB staining and haemorrhage appeared in the thalamus (rCBF 10 ml 100 g-1 min-1) as oedema was decreasing. It is suggested that the amount of oedema and hyperaemia during reperfusion are dependent on the severity of the ischaemia. Areas of moderate ischaemia (8-10 ml 100 g-1 min-1) show little hyperaemia and greater oedema resolution during reperfusion as compared to areas of severe ischaemia (circa 4 ml 100 g-1 min-1) where there is marked hyperaemia with less oedema resolution. Early in the reperfusion period, oedema is not associated with EB staining and indicates a cytotoxic mechanism. The vasogenic component, with macroscopic haemorrhages and leakage of EB occurs later. In this model it is concluded that the early cytotoxic oedema formation and hyperaemia are phenomena with little bearing on mortality, which correlates better with later vasogenic changes.Keywords
This publication has 21 references indexed in Scilit:
- Prostaglandin synthesis and oedema formation during reperfusion following experimental brain ischaemia in the gerbil.Stroke, 1984
- H2 clearance measurement of blood flow: a review of technique and polarographic principles.Stroke, 1980
- Cerebral blood flow and edema following carotid occlusion in the gerbil.Stroke, 1980
- A gerbil model of cerebral ischemia suitable for drug evaluation.Stroke, 1980
- Ischemic brain edema following middle cerebral artery occlusion in baboons: relationship between regional cerebral water content and blood flow at 1 to 2 hours.Stroke, 1979
- Carotid ligation in gerbils. Influence of age, sex, and gonads.Stroke, 1977
- Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.Stroke, 1977
- Patterns of Changes of Blood Flow and Relationships to Infarction in Experimental Cerebral IschemiaStroke, 1976
- Recovery of the cortical evoked response following temporary middle cerebral artery occlusion in baboons: relation to local blood flow and PO2.Stroke, 1976
- The Hydrogen Clearance Method in Assessment of Blood Flow in Cortex, White Matter and Deep Nuclei of BaboonsStroke, 1973