TIMING OF CHEMOTHERAPY AND SURGERY IN A MURINE OSTEO-SARCOMA MODEL
- 1 October 1988
- journal article
- research article
- Vol. 48 (19), 5533-5538
Abstract
The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.This publication has 13 references indexed in Scilit:
- Grading of bone tumors by analysis of nuclear DNA content using flow cytometry.Journal of Bone and Joint Surgery, 1985
- Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.Journal of Clinical Oncology, 1984
- INFLUENCE OF THE INTERVAL BETWEEN PRIMARY TUMOR REMOVAL AND CHEMOTHERAPY ON KINETICS AND GROWTH OF METASTASES1983
- Radiographic and angiographic changes in osteosarcoma after intraarterial chemotherapyAmerican Journal of Roentgenology, 1982
- Preoperative chemotherapy for osteogenic sarcoma:Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapyCancer, 1982
- Radiation-induced osteogenic sarcoma of C3H mouse: Effects of Corynebacterium parvum and WBI on its natural history and response to irradiationEuropean Journal of Cancer (1965), 1979
- Osteogenic SarcomaJournal of Bone and Joint Surgery, 1967
- The development of spontaneous metastases after the removal of a “primary” tumorII. Standardization protocol of 5 animal tumorsCancer, 1961
- EFFECT OF REMOVAL OF A PRIMARY TUMOR ON THE DEVELOPMENT OF SPONTANEOUS METASTASES .1. DEVELOPMENT OF A STANDARDIZED EXPERIMENTAL TECHNIC1959
- An experimental study of postoperative tumor metastases.I. Growth of pulmonary metastases following total removal of primary leg tumorCancer, 1958