Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart
- 22 February 2002
- journal article
- other
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 90 (3), 297-304
- https://doi.org/10.1161/hh0302.104531
Abstract
Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative stress and critical...Keywords
This publication has 30 references indexed in Scilit:
- Enhanced Expression and Activity of Xanthine Oxidoreductase in the Failing HeartJournal of Molecular and Cellular Cardiology, 2000
- β3-adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractilityJCI Insight, 2000
- The Skeletal Muscle Calcium Release ChannelCell, 2000
- Nitrosative Capacity of Macrophages Is Dependent on Nitric-oxide Synthase Induction SignalsPublished by Elsevier ,2000
- Dynamic Regulation of Endothelial Nitric Oxide Synthase: Complementary Roles of Dual Acylation and Caveolin InteractionsBiochemistry, 1998
- Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.The Journal of general physiology, 1996
- Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?Biochemical and Biophysical Research Communications, 1996
- Relation between ventriculoarterial coupling and myocardial energetics in patients with idiopathic dilated cardiomyopathyJournal of the American College of Cardiology, 1994
- Evidence of oxidative stress in chronic heart failure in humansEuropean Heart Journal, 1993
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985