Studies on the Regulation of Fatty Acid and Cholesterol Synthesis in Avian Liver

Abstract

Homogenates of pigeon liver have been incubated with acetate-C¹⁴ in excess. Simultaneously, substrate for glycolysis was provided as glucose-6-phosphate. The incorporation of carbon-14 into cholesterol was maximal at low levels of glycolysis, whereas fatty acid turnover was maximum at higher glycolytic levels. A regulatory mechanism is proposed to explain the differential synthesis of cholesterol and fatty acids.