Evidence for the involvement of superoxide in vitamin K-dependent carboxylation of glutamic acid residues of prothrombin
- 15 July 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 174 (1), 345-348
- https://doi.org/10.1042/bj1740345
Abstract
The formation of vitamin K epoxide and the vitamin K-dependent carboxylation of glutamic acid residues present in synthetic substrates and decarboxyprothrombin are both inhibited by superoxide dismutase. Catalase only inhibits the generation of vitamin K epoxide, suggesting that the carboxylation and epoxidation reactions are not inter-dependent.This publication has 22 references indexed in Scilit:
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