Effect of EGTA on Protein Release and Cyclic AMP Accumulation in Rat Parotid Gland

Abstract

An attempt was made to determine whether accumulation of cyclic AMP (cAMP) was essential for epinepnrine-stimuiated secretion of protein from the rat parotid gland in vitro. EGTA (10⁻² M) did not inhibit secretion but did reduce cAMP accumulation by 80% suggesting that this nucleotide may not be an essential intermediate in the epinephrine-stimuiated secretion process.