The Effect of Administration of Pantothenic Acid on the Histopathology of the Filtrate Factor Deficiency State in Rats

Abstract

The adrenal lesions, abnormal testicular function, and cartilage hypoplasia occurring in rats fed on a diet deficient in the "filtrate factor" are markedly affected by supplementing the diet with 100 [gamma] of pantothenic acid daily. Arrest and repair of adrenal lesions occur, testicular function is improved, and skeletal growth is accelerated. Rats may develop a partial or complete adrenal cortical insufficiency on the deficient diet.