Selective Amine Recognition: Development of a Chemosensor for Dopamine and Norepinephrine
- 11 September 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (21), 3727-3730
- https://doi.org/10.1021/ol048625f
Abstract
A boronic acid-containing coumarin aldehyde was designed and synthesized. The sensor binds to catecholamines such as dopamine and norepinephrine by forming an iminium ion with the amine as well as a boronate ester with the catechol. An internal hydrogen bond produces a colorimetric response to these analytes with good selectivity for catecholamines over simple amines. The fluorescence of the sensor is quenched by the catechol.Keywords
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