Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis
- 1 January 2008
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 15 (1), 168-171
- https://doi.org/10.1128/cvi.00364-07
Abstract
We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.Keywords
This publication has 21 references indexed in Scilit:
- Follow-Up Study of Tuberculosis-Exposed Supermarket Customers with Negative Tuberculin Skin Test Results in Association with Positive Gamma Interferon Release Assay ResultsClinical and Vaccine Immunology, 2007
- Usefulness of Whole-Blood Interferon-γ Assay and Interferon-γ Enzyme-Linked Immunospot Assay in the Diagnosis of Active Pulmonary TuberculosisChest, 2007
- Interferon- Release Assays Improve the Diagnosis of Tuberculosis and Nontuberculous Mycobacterial Disease in Children in a Country with a Low Incidence of TuberculosisClinical Infectious Diseases, 2007
- Comparison of an ESAT-6/CFP-10 Peptide-Based Enzyme-Linked Immunospot Assay to a Tuberculin Skin Test for Screening of a Population at Moderate Risk of Contracting TuberculosisClinical and Vaccine Immunology, 2007
- Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in childrenThorax, 2006
- Comparison of two commercial interferon-γ assays for diagnosingMycobacterium tuberculosisinfectionEuropean Respiratory Journal, 2006
- Specific T-Cell Epitopes for Immunoassay-Based Diagnosis ofMycobacterium tuberculosisInfectionJournal of Clinical Microbiology, 2004
- Recomendaciones separ. normativa sobre la prevención de la tuberculosisArchivos de Bronconeumología, 2002
- Enumeration of T Cells Specific for RD1‐Encoded Antigens Suggests a High Prevalence of LatentMycobacterium tuberculosisInfection in Healthy Urban IndiansThe Journal of Infectious Diseases, 2001
- The Tuberculin Skin TestClinical Infectious Diseases, 1993