Putative functional domain within ORF2 on the Mycobacterium insertion sequences IS900 and IS902
- 1 October 1994
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 72 (5), 427-434
- https://doi.org/10.1038/icb.1994.63
Abstract
Repeated DNA sequences have been identified in a range of mycobacterial species and have been implicated in the increased virulence of some of these species, namely, Mycobacterium paratuberculosis and M. avium subsp. silvaticum. Here we present a case to suggest that the insertion sequences IS900 and IS902 encode a protein from a putative gene positioned on the complementary strand to their transposase genes. Based on amino acid homology analyses, this open reading frame (ORF2) could encode a transport protein. The ORF2 protein thus IS900 and IS902, may have a role in the increased pathogenicity of M. paratuberculosis and M. avium subsp. silvaticum from an M. avium background.Keywords
This publication has 27 references indexed in Scilit:
- Expression of the ferric enterobactin receptor (PfeA) of Pseudomonas aeruginosa: involvement of a two‐component regulatory systemMolecular Microbiology, 1993
- Iron and infection: Better understanding at the molecular level but little progress on the clinical frontJournal of Medical Microbiology, 1993
- p43, the protein product of the atypical insertion sequence IS900, is expressed in Mycobacterium paratuberculosisJournal of General Microbiology, 1992
- Bacterial cytochromes c biogenesis.Genes & Development, 1992
- IS902, an insertion element of the chronic-enteritis-causing Mycobacterium avium subsp. silvaticumJournal of General Microbiology, 1992
- Cloning of a Serotonin Transporter Affected by AntidepressantsScience, 1991
- Molecular analysis of the Escherichia coli K5 kps locus: identification and characterization of an inner‐membrane capsular polysaccharide transport systemMolecular Microbiology, 1990
- Discovery of an insertion sequence, IS116, from Streptomyces clavuligerus and its relatedness to other transposable elements from actinomycetesJournal of General Microbiology, 1990
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- The production in bovine calves of a disease resembling paratuberculosis with a Mycobacterium sp isolated from a woodpigeon (Columba palumbus L)Published by Wiley ,1979