Distribution and postprandial release of porcine peptide YY

Abstract

Peptide YY (PYY), a thirty-six amino acid intestinal hormonal peptide with a tyrosine residue at each end (hence YY as Y represents tyrosine in the new peptide nomenclature), was found throughout the gastrointestinal tract of the pig. Concentrations were very low in the foregut (antrum, 3·4 ± 0·3 pmol/g; duodenum, 1·1 ± 1·5 pmol/g), higher in the distal small intestine (ileum, 100 ± 13 pmol/g) and very high in the large bowel (descending colon, 270 ± 45 pmol/g). Peptide YY was found to circulate in plasma and concentrations rose substantially in response to eating (fasting, 138 ± 15 pmol/l; postprandial, 263 ± 21 pmol/l; PJ. Endocr. (1987) 113, 11–14