Bone Histomorphometry in Hypogonadal and Eugonadal Men with Spinal Osteoporosis*
- 1 July 1987
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 65 (1), 53-58
- https://doi.org/10.1210/jcem-65-1-53
Abstract
We present iliac bone histomorphometric data after in vivo double tetracycline labeling and related biochemical data from 14 nonalcoholic men referred for evaluation of symptomatic spinal osteoporosis. Six patients had previously undiagnosed hypogonadism, and 8 had normal gonadal function and no evident etiology for osteoporosis. Bone histomorphometry revealed no differences in structural measurements or resorption indices between the 2 groups. However, compared to reference values for normal postmenopausal women, osteoblast surface, mineralizing surface, and formation rate were normal or modestly increased in th hypogonadal men and significantly reduced in the idiopathic group. There were significant corresponding differences between the 2 groups in the fasting urinary hydroxyproline to creatinine ratio, an index of bone resorption, and serum total alkaline phosphatase, an index of bone formation. Plasma 25-hydroxyvitamin D levels did not differ between the 2 groups and were above 10 ng/mL in all patients. Plasma 1,25-dihydroxyvitamin D [1,25-(OH)2D] levels were normal in the hypogonadal group and significantly reduced in the idiopathic group, but did not correlate with any histological measurements. The formation indices fell substantially in 3 of 4 hypogonadal men after 7-14 months of therapy with testosterone and a calcium supplement. We conclude the following. 1) In vitamin D-replete hypogonadal men with osteoporosis, 1,25-(OH)2D synthesis is normal, and bone remodeling is modestly increased and correctable by hormone replacement therapy, as in normal postmenopausal women. 2) In middle-aged men with idiopathic osteoporosis, there is impairment of 1,25-(OH)2D synthesis and of the recruitment and activity of teams of osteoblasts, as in postmenopausal osteoporosis.This publication has 21 references indexed in Scilit:
- Symptomatic Osteoporosis in a Man with Hyperprolactinemic HypogonadismAnnals of Internal Medicine, 1986
- Osteoporosis in Men with Hyperprolactinemic HypogonadismAnnals of Internal Medicine, 1986
- Bone Disease in Alcohol AbuseAnnals of Internal Medicine, 1985
- Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.JCI Insight, 1981
- Testosterone metabolism in human boneActa Endocrinologica, 1980
- Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal maleCalcified Tissue International, 1978
- Tetracycline double-labeling of iliac trabecular bone in 41 normal adultsCalcified Tissue International, 1978
- MENOPAUSAL CHANGES IN BONE REMODELING1978
- CHANGES IN THE PITUITARY‐TESTICULAR SYSTEM WITH AGEClinical Endocrinology, 1976
- Modifications of a specific assay for hydroxyproline in urineAnalytical Biochemistry, 1967