An Investigation into the Action of Bases on Chloroform*
- 1 September 1959
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 11 (1), 400-410
- https://doi.org/10.1111/j.2042-7158.1959.tb12572.x
Abstract
The reaction of a number of bases with chloroform has been studied by titration of the liberated halide ion. The results are interpreted in the light of strength of the base, and steric factors. The examination of solutions of strong bases such as piperidine and pyrrolidine in chloroform B.P. indicates that the base reacts with an impurity present. This paper provides additional confirmation, to that obtained by Caws and Foster, of the presence of reactive halogeno-hydrocarbons in this solvent. Methods are also described for assessing the quality of a sample of chloroform B.P., and for preparing chloroform free from these reactive impurities.Keywords
This publication has 25 references indexed in Scilit:
- Steric Effects in Displacement Reactions. II. The Rates of Reaction of Alkyl Iodide s with the Monoalkylpyridines. Steric Strain in the Activated ComplexJournal of the American Chemical Society, 1955
- Steric Effect of Methylene Groups. VIJournal of the American Chemical Society, 1952
- Acid-Base Studies in Gaseous Systems. VII. Dissociation of the Addition Compounds of Trimethylboron and Cyclic Imines; I-StrainJournal of the American Chemical Society, 1950
- Carbon Dichloride as an Intermediate in the Basic Hydrolysis of Chloroform. A Mechanism for Substitution Reactions at a Saturated Carbon Atom1Journal of the American Chemical Society, 1950
- Studies in Stereochemistry. XIV. Reaction of Triethylamine and Quinuclidine with Alkyl Halides; Steric Effects in Displacement ReactionsJournal of the American Chemical Society, 1949
- Dissociation of the Addition Compound of Trimethylboron with Quinuclidine; Further Evidence for the Steric Configuration of Triethylamine1Journal of the American Chemical Society, 1948
- Dissociation of the Addition Compounds of Trimethylboron with the Ethylamines; Configuration of the Ethylamines1Journal of the American Chemical Society, 1947
- Dissociation of the Compounds of Trimethylboron with Pyridine and the Picolines; Evidence for the Steric Nature of the Ortho Effect1Journal of the American Chemical Society, 1947
- Steric Factors in Quaternary Salt FormationJournal of the American Chemical Society, 1943
- THE REACTION OF ORGANIC HALIDES WITH PIPERIDINE. I. ALKYL BROMIDESJournal of the American Chemical Society, 1931