Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens
- 6 November 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 257 (2), 457-459
- https://doi.org/10.1016/0014-5793(89)81595-9
Abstract
The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.Keywords
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