The SREBP pathway — insights from insigs and insects
- 1 August 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (8), 631-640
- https://doi.org/10.1038/nrm1174
Abstract
Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role for the SREBP pathway in integrating membrane composition and lipid biosynthesis.Keywords
This publication has 81 references indexed in Scilit:
- Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ERProceedings of the National Academy of Sciences, 2002
- SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverJournal of Clinical Investigation, 2002
- Mutant Mammalian Cells as Tools to Delineate the Sterol Regulatory Element-Binding Protein Pathway for Feedback Regulation of Lipid SynthesisArchives of Biochemistry and Biophysics, 2002
- Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER MembranesCell, 2000
- Regulated Intramembrane ProteolysisCell, 2000
- A proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodProceedings of the National Academy of Sciences, 1999
- The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription FactorCell, 1997
- SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.Proceedings of the National Academy of Sciences, 1993
- ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.Molecular and Cellular Biology, 1993
- 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoterCell, 1987