THE EFFECT OF PROLONGED ADMINISTRATION OF SULFANILAMIDE ON RATS WITH NEPHROTOXIC NEPHRITIS
Open Access
- 1 November 1939
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 18 (6), 757-762
- https://doi.org/10.1172/jci101091
Abstract
Sulfanilamide, given in therapeutic doses for long periods to rats with nephrotoxic nephritis, did not affect the course of the exptl. disease. Rats with nephrotoxic nephritis, but without renal failure, excreted sulfanilamide in the same amts. as did normal rats. Incidently, it was found that rats of the Whelan and Evans strains responded differently to the effect of nephrotoxic serum and diet.This publication has 3 references indexed in Scilit: