Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

Abstract

Murine skin tumors induced by chronic treatment with ultraviolet (UV) light exhibited an unexpectedly high degree of antigenicity compared with tumors induced by chemical carcinogens. UV-induced spindle cell tumors completely regressed when transferred to normal syngeneic recipients and grew progressively only in immunosuppressed hosts. Squamous cell carcinomas produced by UV light also showed this unusual behavior, but to a lesser extent. No cross-reactivity was detected among these tumors by in vivo cross-protection tests.