PRIMARY CHORIOCARCINOMA OF LUNG - CASE-REPORT OF 2 MALE SUBJECTS

Abstract

Extragenital choriocarcinoma in the male is known to occur in retroperitoneum, mediastinum and pineal body in a high proportion, and there were no certain reports of lung origin. Two cases of choriocarcinoma arising from the lung in the male were studied by histological, EM, immunofluorescent and immunoenzyme methods. Histologically, characteristic changes of choriocarcinoma, composed of irregular complex of cytotrophoblasts and syncytiotrophoblasts with massive necrosis and hemorrhage were demonstrated. These 2 cell patterns, characteristic of choriocarcinoma, were also demonstrated by EM and differed from giant cell carcinoma of the lung. By immunofluorescent and immunoenzyme methods, anti-HCG [human chorionic gonadotropin] reactive particles were seen in the cytoplasm of syncytiotrophoblasts and proved HCG production by the tumor.