Serum Osteocalcin Is Increased in Patients with Hyperthyroidism and Decreased in Patients Receiving Glucocorticoids*
- 1 May 1986
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 62 (5), 1056-1058
- https://doi.org/10.1210/jcem-62-5-1056
Abstract
Osteocalcin (OC) is a vitamin K-dependent protein which is synthesized by osteoblasts and is present in the circulation. We measured serum OC concentrations in 10 patients receiving corticosteroids (CS) for chronic obstructive pulmonary disease and in 9 hyperthyroid (HT) patients. Mean values (±SE) were as follows: There was a significant correlation between OC and alkaline phosphatase (r = 0.607; P = 0.006) when CS and HT groups were combined. Elevated serum OC concentrations in hyperthyroid patients may reflect increased osteoblastic activity, while decreased levels in corticosteroid-treated patients may reflect decreased osteo-blastic activity.Keywords
This publication has 5 references indexed in Scilit:
- SERUM BONE GLA-PROTEIN: A SPECIFIC MARKER FOR BONE FORMATION IN POSTMENOPAUSAL OSTEOPOROSISThe Lancet, 1984
- Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoidsMetabolic Bone Disease and Related Research, 1984
- Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosisCalcified Tissue International, 1983
- Measurements of γ-carboxyglutamate and circulating osteocalcin in normal children and adultsClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- A Tetracycline‐Based Histomorphometric Evaluation of Bone Resorption and Bone Turnover in Hyperthyroidism and HyperparathyroidismActa Medica Scandinavica, 1978