Enzymatic Degradation of Side-Chain of Cortisone: Intracellular Localization of the Enzyme System.
- 1 May 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 89 (1), 156-159
- https://doi.org/10.3181/00379727-89-21744
Abstract
The intracellular localization of an enzyme system which alters the 17,21-dihydroxy-20-ketone side-chain of cortisone was studied in rat liver. The nuclei and mitochondria were inactive. The enzyme was approximately equally distributed between a microsome fraction sedimented at 20,000 x gravity and the supernatant fraction. The enzyme activity was greatly enhanced on addition of Mg and either glucoses-phosphate, citrate, or isocitrate.Keywords
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