Identification of producer and biological activities of new antibiotics, mimosamycin and chlorocarcins.

Abstract

A strain of Streptomyces, No. 314 identified as a S. lavendulae, produced under a novel condition of culture 4 new antibiotics, mimosamycin and chlorocarcins A, B and C. Among the components of chlorocarcin complex, chlorocarcin A was most biologically active. This antibiotic inhibited the growth of Staphylococcus aureus FDA 209P and Corynebacterium diphtheriae at the concentrations of 0.1 and 0.003 .mu.g/ml, respectively. Chlorocarcin A also exhibited antitumor activity on Ehrlich carcinoma, ascitic and solid forms, and mouse leukemia L1210. Mimosamycin was mainly active on Mycobacterium tuberculosis and inactive on the experimental murine tumors.