Survey on Substrate Specificity with Regard to ATP Analogs of Aminoacyl-tRNA Synthetases fromE. coliand from Baker’s yeast. Correlation to Synthetase Families

Abstract
The substrate specificity of 20 aminoacyl-tRNA synthetases from E. coli and 13 enzymes from baker''s yeast with regard to 8 ATP analogs is investigated for a comparison of the active-site topography. The enzymes are arranged in a scheme of possible enzyme families and compared to earlier schemes.