Insulin, Glucagon, and Glucose Exhibit Synchronous, Sustained Oscillations in Fasting Monkeys
- 14 January 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4274), 177-179
- https://doi.org/10.1126/science.401543
Abstract
In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in man, regular oscillations were not observed.This publication has 20 references indexed in Scilit:
- A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas.Journal of Clinical Investigation, 1975
- Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.Journal of Clinical Investigation, 1975
- The Effect of Adrenergic Blockade on the Glucagon Responses to Starvation and Hypoglycemia in ManJournal of Clinical Investigation, 1974
- Human Prolactin: 24-Hour Pattern with Increased Release during SleepScience, 1972
- Circhoral Oscillations of Plasma LH Levels in the Ovariectomized Rhesus Monkey1,2Endocrinology, 1970
- High frequency blood glucose oscillations in manMetabolism, 1968
- Electrical Activity in Pancreatic Islet CellsNature, 1968
- Fluctuations in postabsorptive blood glucose in relation to insulin releaseMetabolism, 1967
- Reciprocal Influences of the Ventromedial and Lateral Hypothalamic Nuclei on Blood Glucose Level and Liver Glycogen ContentNature, 1966
- SPONTANEOUS FLUCTUATIONS IN GLUCOSE CONTENT OF THE HEPATIC VENOUS BLOOD IN RESTING NORMAL HUMAN BEINGSJournal of Clinical Investigation, 1952