THE ACTIVITY OF THE BLOOD SERUM AMYLASE IN THE HYPOPHYSECTOMIZED DOG

Abstract

Six dogs were hypophysectomized by a parapharyngeal approach. A control operation was performed on a 7th. Observations of the blood serum amylase activity before hypophysectomy confirmed the absence of effect of food, fasting, glucose, and insulin. Adrenin effected a slight rise. Hypophysectomy resulted in a precipitous rise in the 2d 24 hrs., reaching a maximum at 48 hrs. which was maintained throughout life. The rise represented more than a 2-fold increase in activity. It did not appear in the operative control. The ant. pituitary evidently exerted a major influence in the control of blood serum amylase activity.