Polymer-supported acidolysis of protecting groups used in the synthesis of large peptides
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 530-531
- https://doi.org/10.1039/c39910000530
Abstract
Amino acids and several peptides containing benzyl and other protecting groups normally removable by superacids such as HF, dissolved in trifluoroacetic acid, underwent novel acidolytic deprotection by Nafion polymers.Keywords
This publication has 10 references indexed in Scilit:
- Trimethylsilyl trifluoromethanesulphonate as a useful deprotecting reagent in both solution and solid phase peptide synthesesJournal of the Chemical Society, Chemical Communications, 1987
- Perfluorinated Resinsulfonic Acid (Nafion-H®) Catalysis in SynthesisSynthesis, 1986
- Synthesis of protected peptide segments and their assembly on a polymer-bound oxime: application to the synthesis of a peptide model for plasma apolipoprotein A-IThe Journal of Organic Chemistry, 1983
- Cleavage of α-Ketoacetals by Catalysis with the Solid Superacid Nafion-H®Synthesis, 1983
- Solid-phase synthesis of protected peptides on a polymer-bound oxime: preparation of segments comprising the sequence of a cytotoxic 26-peptide analogThe Journal of Organic Chemistry, 1982
- Silylation with a perfluorinated resinsulfonic acid trimethylsilyl esterTetrahedron Letters, 1980
- Polymer-bound oxime esters as supports for solid-phase peptide synthesis. The preparation of protected peptide fragmentsThe Journal of Organic Chemistry, 1980
- Trifluoromethanesulphonic acid, as a deprotecting reagent in peptide chemistryJournal of the Chemical Society, Chemical Communications, 1974
- Boron Tris(trifluoroacetate) for Removal of Protecting Groups in Peptide ChemistryAngewandte Chemie International Edition in English, 1973
- Use of Anhydrous Hydrogen Fluoride in Peptide Synthesis. I. Behavior of Various Protective Groups in Anhydrous Hydrogen FluorideBulletin of the Chemical Society of Japan, 1967