Effect of splanchnicotomy on the renal excretion of uric acid in anaesthetzed dogs

Abstract

The renal excretion of uric acid was examined during acute i.v. urate (Ua) loading on unilaterally splanchnicotomized (“renal denervation”) anaesthetize mongrel dogs. Glomerular filtration rate (GFR) in general was not different in innervated and denervated kidneys, whereas urine flow (V) and urinary excretion of sodium (U_NaV) on the splanchnicotomized side were significantly increased at any plasma concentration of Ua. The excretion (U_UaV) and tubular transport (T_Ua) of urate calculated for unit GFR were considerably increased and depressed, respectively, at normal plasma Ua level and during minor urate loading (plasma concentration up to 4.7 mg%). Above this plasma level, i.e. up to 24.6 mg%, no difference in net urate reabsorption between intact and sympathectomized organs was found. It is suggested that both reabsorption and secretion of Ua in denervated kidneys are diminished.