Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis
- 5 July 2000
- journal article
- Published by Springer Nature in Oncogene
- Vol. 19 (29), 3256-3265
- https://doi.org/10.1038/sj.onc.1203654
Abstract
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression. We used the well-characterized Rat1AmycERT cells to show that the caveolin-1 gene is down-regulated at the level of transcription by c-myc. By maintaining relatively high levels of caveolin-1 with an adenoviral vector or in stably transfected clones we show that caveolin-1 can suppress c-myc-induced apoptosis. Further we established human prostate cancer cell lines with the mycER construct and show that clones with increased caveolin-1 are more resistant to myc-induced apoptosis and have increased capacity for growth in soft agar when c-myc is activated.Keywords
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