An abnormal pattern of amniotic fluid microvillar enzymes signalling fetal cystic fibrosis

28 June 2008

journal article
research article
Published by Wiley in Clinical Genetics

Vol. 31 (3), 182-185
https://doi.org/10.1111/j.1399-0004.1987.tb02792.x

Abstract

We have observed seven pregnancies at risk for fetal cystic fibrosis where second-trimester amniotic fluid microvillar enzyme activities presented an unusual pattern. Low .gamma.-glutamyltranspeptidase and borderline .alpha.-glucosidase values were associated with normal aminopeptidase M and intestinal alkaline phosphatase values. All seven pregnancies went to term; five of the seven infants were affected with cystic fibrosis.

Keywords

This publication has 12 references indexed in Scilit:

Prenatal diagnosis of cystic fibrosis by trehalase enzyme assay in amniotic fluid
Clinical Genetics, 2008
Biochemical analysis of meconium in fetuses presumed to have cystic fibrosis
Prenatal Diagnosis, 1986
PROSPECTIVE PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS
The Lancet, 1985
A comparative study of microvillar enzyme activities in the prenatal diagnosis of cystic fibrosis
Prenatal Diagnosis, 1985
Prenatal diagnosis of cystic fibrosis: I. Prospective study of 51 pregnancies
Prenatal Diagnosis, 1985
Amniotic fluid disaccharidases in the prenatal detection of cystic fibrosis
Prenatal Diagnosis, 1985
Microvillar enzyme analysis in amniotic fluid and the prenatal diagnosis of cystic fibrosis
Prenatal Diagnosis, 1985
Prenatal diagnosis of cystic fibrosis by assay of amniotic fluid microvillar enzymes
Human Genetics, 1984
AMNIOTIC FLUID ALKALINE PHOSPHATASE ISOENZYMES IN EARLY PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS
The Lancet, 1983
MICROVILLAR PEPTIDASE ACTIVITY IN AMNIOTIC FLUID: POSSIBLE USE IN THE PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS
The Lancet, 1983

Cited by 4 articles