Composite Electrode Tips Containing Externally Placed Drug Releasing Collars
- 1 November 1988
- journal article
- research article
- Published by Wiley in Pacing and Clinical Electrophysiology
- Vol. 11 (11), 1760-1769
- https://doi.org/10.1111/j.1540-8159.1988.tb06307.x
Abstract
We have developed a composite electrode tip based on a new concept whereby the electrode is combined with a polymeric collar containing dexamethasone sodium phosphate (DSP). The collar is positioned immediately adjacent to the electrode. Initial evaluation of this concept employed the Telectronics Laserpor electrode and a collar containing approximately 1.8 mg of DSP (LPD). Conventional Telectronics Laserpor (LP) electrodes were used as controls. Further evaluation was performed using a DSP (less than 0.5 mg) eluting collar and a new 4 mm2 mushroom shaped electrode with a high microsurface Pt/Ir coating (MD). Data for conventional Telectronics Laserdish (LD) electrodes were used for comparison. Unipolar ventricular leads were implanted transvenously in the right ventricular apex of sheep. Voltage thresholds, pacing (5 V, 0.5 ms) and sensing (50/100 mV RMS, 50 Hz) impedances were measured during the subchronic phase (less than 6 weeks) and in the case of LD and MD for 6 months. The steroid eluting electrodes were effective in eliminating (2 weeks vs. Impl., N.S.) the 2 week threshold peaking seen with the control leads (2 weeks vs. Impl., P less than 0.005). The small area MD electrode thresholds remained stable and low for up to 6 months (0.38 +/- 0.09 (10) c.f. 0.46 +/- 0.11(6); 14 and 180 days, respectively, N.S.). The composite electrode tips with steroid releasing collars thus show great potential for a substantial reduction in stimulation energy.Keywords
This publication has 6 references indexed in Scilit:
- Composite Electrode Tips Containing Externally Placed Drug Releasing CollarsPacing and Clinical Electrophysiology, 1988
- The Porous Titanium Steroid Eluting Electrode: A Double Blind Study Assessing the Stimulation Threshold Effects of SteroidPacing and Clinical Electrophysiology, 1988
- Clinical Experience with 910 Carbon Tip Leads: Comparison with Polished Platinum Leads.Pacing and Clinical Electrophysiology, 1986
- Acute and Long‐Term Atrial and Ventricular Stimulation Thresholds with a Steroid‐Eluting ElectrodePacing and Clinical Electrophysiology, 1985
- Characteristles of Advanced Porous and Textured Surface Pacemaker ElectrodesPacing and Clinical Electrophysiology, 1983
- The effect of dexamethasone on formation of a fibronectin extracellular matrix by rat hepatocytes in vitroExperimental Cell Research, 1980