The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 35 (4), 1270-1273
- https://doi.org/10.1021/bi952168g
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Recombinant Human Dihydroorotate Dehydrogenase: Expression, Purification, and Characterization of a Catalytically Functional Truncated EnzymeArchives of Biochemistry and Biophysics, 1995
- Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivativesBioorganic & Medicinal Chemistry Letters, 1995
- Inhibition of Protein Tyrosine Phosphorylation in T Cells by a Novel Immunosuppressive Agent, LeflunomideJournal of Biological Chemistry, 1995
- LEFLUNOMIDE CONTROLS REJECTION IN HAMSTER TO RAT CARDIAC XENOGRAFTSTransplantation, 1994
- LEFLUNOMIDE IN EXPERIMENTAL TRANSPLANTATIONTransplantation, 1994
- The Development of Brequinar as an Immunosuppressive Drug for TransplantationImmunological Reviews, 1993
- Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomideFEBS Letters, 1993
- Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejectionInflammation Research, 1991
- FK-506: Profile of an important new immunosuppressantTransplantation Reviews, 1990
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973