Effect of Acute Extracellular Volume Expansion on Cross-Circulated Dogs

Abstract

Pairs of dogs receiving vasopressin and mineralocorticoids underwent femoral artery to femoral vein cross-circulation while one member of each pair (donor) received an intravenous infusion of Ringer’s lactate. No significant increase in urinary sodium excretion (U_NaV), filtered load of sodium (F_Na) or renal hemodynamics occurred in the non-infused recipients during the first hour of infusion of the donors. It is concluded that a systemic humoral mediator for the depression of tubular reabsorption of sodium in response to acute extracellular fluid volume expansion was not demonstrable under the conditions of this study.