Prüfung einiger Alkaloide auf eine Mitosegiftwirkung

Abstract

The alkaloid colchicine, a series of derivatives prepared from it, and a series of similar synthetic compounds are active mitosis poisons, as determined by their effects on the growth of chicken heart fibroblasts. These compounds contain a suitably substituted [alpha],[beta]-diphenylethylamine group (stilbylamine group). It was found that 25 alkaloids which do not contain this group do not act as mitosis poisons. The alkaloids with the stilbylamine group can be divided into: 1) The colchicine type; 2) the papaverine type; 3) the berberine type; and 4) the chelidonine type. The only alkaloid of the 1st type available to the authors was apomorphine, and it showed no action on mitosis in a dose of 75 [gamma] per ml. of culture medium. Of 16 compounds of the 2d type tested only narcotine acted as a mitosis poison. None of the compounds of the 3d type tested acted as mitosis poisons. Compounds of the 4th type which are mitosis poisons are: chelidonine, homochelidonine and methoxychelidonine. Chelerythrine and sanguinarine, which are hydrogenation products of chelidonine, have no action on mitosis. Further study is needed to det. what constitutional factors make the alkaloids active mitosis poisons.