Transforming Growth Factors β1 and α in Chronic Liver Disease
Open Access
- 4 April 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 324 (14), 933-940
- https://doi.org/10.1056/nejm199104043241401
Abstract
Cirrhosis is a diffuse process of hepatic fibrosis and regenerative nodule formation of unknown pathogenesis. Transforming growth factor (TGF) β1 induces the production of extracellular matrix proteins by liver cells and has been implicated in the pathogenesis of hepatic fibrosis in laboratory animals. TGFα is a hepatocyte mitogen that participates in liver regeneration.Keywords
This publication has 38 references indexed in Scilit:
- Randomized trial of lymphoblastoid alpha interferon in chronic non-A, non-B hepatitis: Effects on inflammation and fibrogenesisJournal of Hepatology, 1989
- Recombinant Interferon Alfa Therapy for Chronic Hepatitis CNew England Journal of Medicine, 1989
- Treatment of Chronic Hepatitis C with Recombinant Interferon AlfaNew England Journal of Medicine, 1989
- Suppressor T-cell activity in chronic hepatitis B-virus infection: Relationship with the presence of HBV-DNA in serumJournal of Medical Virology, 1989
- Liver fibrosis and extracellular matrixJournal of Hepatology, 1989
- Colchicine in the Treatment of Cirrhosis of the LiverNew England Journal of Medicine, 1988
- Treatment of Chronic Non-A, Non-B Hepatitis with Recombinant Human Alpha InterferonNew England Journal of Medicine, 1986
- Early alcoholic liver injuryJournal of Hepatology, 1986
- Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary cultureBiochemical and Biophysical Research Communications, 1985
- Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis†Hepatology, 1981