A superfamily of metalloenzymes unifies phosphopentomutase and cofactor‐independent phosphoglycerate mutase with alkaline phosphatases and sulfatases
Open Access
- 1 August 1998
- journal article
- for the-record
- Published by Wiley in Protein Science
- Vol. 7 (8), 1829-1835
- https://doi.org/10.1002/pro.5560070819
Abstract
Sequence analysis of the probable archaeal phosphoglycerate mutase resulted in the identification of a superfamily of metalloenzymes with similar metal‐binding sites and predicted conserved structural fold. This superfamily unites alkaline phosphatase, N‐acetylgalactosamine‐4‐sulfatase, and cerebroside sulfatase, enzymes with known three‐dimensional structures, with phosphopentomutase, 2,3‐bisphosphoglycerate‐independent phosphoglycerate mutase, phosphoglycerol transferase, phosphonate monoesterase, streptomycin‐6‐phosphate phosphatase, alkaline phosphodiesterase/nucleotide pyrophosphatase PC‐1, and several closely related sulfatases. In addition to the metal‐binding motifs, all these enzymes contain a set of conserved amino acid residues that are likely to be required for the enzymatic activity. Mutational changes in the vicinity of these residues in several sulfatases cause mucopolysaccharidosis (Hunter, Maroteaux‐Lamy, Morquio, and Sanfilippo syndromes) and metachromatic leucodystrophy.Keywords
This publication has 71 references indexed in Scilit:
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Cloning and Expression of the Unique Ca2+-ATPase from Flavobacterium odoratumPublished by Elsevier ,1996
- A D255H substitution in the arylsulphatase A gene of two unrelated Belgian patients with late‐infantile metachromatic leukodystrophyJournal of Inherited Metabolic Disease, 1996
- Purification and Characterization of the Ca2+-ATPase of Flavobacterium odoratumJournal of Biological Chemistry, 1996
- Mutations at Positions 153 and 328 inEscherichia coliAlkaline Phosphatase Provide Insight Towards the Structure and Function of Mammalian and Yeast Alkaline PhosphatasesJournal of Molecular Biology, 1995
- The carboxyphosphonoenolpyruvate synthase-encoding gene from the bialaphos-producing organism Streptomyces hygroscopicusGene, 1995
- Wheat germ phosphoglycerate mutase: Evidence for a metalloenzymeBiochemical and Biophysical Research Communications, 1986
- Wheat germ phosphoglycerate mutase: Purification, polymorphism, and inhibitionBiochemical and Biophysical Research Communications, 1985
- Phosphoglycerate mutase in developing forespores of Bacillusmegaterium may be regulated by the intrasporal level of free manganous ionBiochemical and Biophysical Research Communications, 1978
- Phosphodeoxyribomutase from Escherichia coliEuropean Journal of Biochemistry, 1970